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HELIC - HELlenic Isolated Cohorts

Hellenic Isolated Cohorts (HELIC). With our collaborators at Harokopio University in Athens, the Wellcome Sanger Institute is investigating the effects of such genetic variants in two isolated populations in Greece. The HELIC cohort collection, including biological samples and extensive phenotype data, started in 2009. We aim to investigate the association of low-frequency and rare variants with complex traits of medical relevance employing whole-genome sequencing approaches.

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HELIC - HELlenic Isolated Cohorts | helic.org Reviews
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Hellenic Isolated Cohorts (HELIC). With our collaborators at Harokopio University in Athens, the Wellcome Sanger Institute is investigating the effects of such genetic variants in two isolated populations in Greece. The HELIC cohort collection, including biological samples and extensive phenotype data, started in 2009. We aim to investigate the association of low-frequency and rare variants with complex traits of medical relevance employing whole-genome sequencing approaches.
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HELIC - HELlenic Isolated Cohorts | helic.org Reviews

https://helic.org

Hellenic Isolated Cohorts (HELIC). With our collaborators at Harokopio University in Athens, the Wellcome Sanger Institute is investigating the effects of such genetic variants in two isolated populations in Greece. The HELIC cohort collection, including biological samples and extensive phenotype data, started in 2009. We aim to investigate the association of low-frequency and rare variants with complex traits of medical relevance employing whole-genome sequencing approaches.

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Publications - HELlenic Isolated Cohorts

https://www.helic.org/publications.html

Gilly A, Ritchie GR, Southam L, Farmaki AE, Tsafantakis E, Dedoussis G, Zeggini E. Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation. 2016, doi: 10.1093/hmg/ddw088. Zeggini E, Gloyn AL, Hansen T. Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland. 938-41. doi: 10.1007/s00125-016-3926-3. 1352-6. doi: 10.1038/ng.3403. 1272-81. doi: 10.1038/ng.3368. Wessel J, Chu AY, Will...

2

Funding - HELlenic Isolated Cohorts

https://www.helic.org/funding.html

This work is funded by the Wellcome Trust. And the European Research Council (ERC). This site is hosted by the Wellcome Trust Sanger Institute.

3

Investigators - HELlenic Isolated Cohorts

https://www.helic.org/investigators.html

Group Leader, Analytical Genomics of Complex Traits, The Wellcome Trust Sanger Institute. Ele's work aims to help elucidate the genetic determinants of complex human traits by using next-generation association studies to identify novel disease loci. Associate Professor of Biology, Department of Dietetics-Nutrition, Harokopio University, Athens, Greece. George's research focuses on nutrigenetics and lifestyle interactions of complex genetic disorders.

4

Team members - HELlenic Isolated Cohorts

https://www.helic.org/team.html

Emmanouil Tsafantakis (Director of Anogia Health Centre). Maria Karaleftheri (Director of Echinos Health Centre). This site is hosted by the Wellcome Trust Sanger Institute.

5

Collection Sites - HELlenic Isolated Cohorts

https://www.helic.org/sites.html

The HELIC work focuses on two isolated populations, each with information on a wide array of anthropometric, cardiometabolic, biochemical, haematological and diet-related traits. The MANOLIS sub-study (Minoan Isolates) focuses on a set of mountainous villages (Mylopotamos villages) on the island of Crete, Greece. This programme of work is named MANOLIS to honour the memory of Manolis Giannakakis, 1978-2010. The Pomak villages are a set of isolated mountainous villages in the North of Greece.

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Hellenic Isolated Cohorts (HELIC). With our collaborators at Harokopio University in Athens, the Wellcome Sanger Institute is investigating the effects of such genetic variants in two isolated populations in Greece. The HELIC cohort collection, including biological samples and extensive phenotype data, started in 2009. We aim to investigate the association of low-frequency and rare variants with complex traits of medical relevance employing whole-genome sequencing approaches.

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