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Mechanism of Action - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/pipeline/intepirdine-rvt-101/mechanism-of-action
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Intepirdine (RVT-101) is an orally administered, potent antagonist of the 5HT6 receptor. Blocking the 5HT6 receptor promotes the release of acetylcholine, an essential neurotransmitter needed for normal cognition and function. Together, intepirdine and donepezil may work to preserve acetylcholine and improve the cognition and function of patients with mild to moderate Alzheimer’s disease. 2017 Axovant Sciences ...
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Nelotanserin - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/pipeline/nelotanserin
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). We believe that nelotanserin has a number of favorable properties as a product candidate for dementia:. Highly potent and highly selective at the 5HT2A receptor. Minimal or no activity at the 5HT2C, D2 or H1 receptors. Well tolerated in the seven clinical studies completed to date with nearly 800 human subjects exposed to the drug candidate. No evidence of QTc prolongation. Oral, once-daily administration.
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REM Sleep Behavior Disorder (RBD) - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/clinical-trials/rem-sleep-behavior-disorder-rbd
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Axovant is currently conducting a phase 2, multi-center, double-blind, placebo-controlled study evaluating nelotanserin in patients with dementia with Lewy bodies (DLB) experiencing rapid eye movement (REM) sleep behavior disorder (RBD). For more information about the visual hallucinations study evaluating nelotanserin* in patients with Lewy body dementia call 1 (919) 425-0709. Learn More About Nelotanserin.
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HEADWAY-DLB - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/clinical-trials/headway-dlb
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). HEADWAY-DLB is a global Phase 2b multi-center, double-blind, placebo-controlled clinical study evaluating intepirdine (RVT-101) in patients with dementia with Lewy bodies (DLB). HEADWAY-DLB is a Phase 2b clinical research study evaluating intepirdine (RVT-101)* for dementia with Lewy bodies. For more information contact us at HEADWAYDLB@Axovant.com. Or call 1 (646) 677-5778. Learn More About Our Clinical Trials.
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Board of Directors - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/about/board-of-directors
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Lawrence Olanoff, MD, PhD. Atul Pande, MD. Marianne L. Romeo. Gary Pisano, PhD. Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). 2017 Axovant Sciences Ltd. Privacy Policy.
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Alzheimer's Disease - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/knowledge-center/about-dementia/alzheimers-disease
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Alzheimer’s disease is the most common form of dementia and the sixth leading cause of death in the United States. Alzheimer’s Association Alzheimer’s Disease Facts and Figures 2014 and 2015; Barnes and Yaffe, Lancet Neurology, 2011 Sep; 10(9): 819-28. In 2015, total healthcare costs for Alzheimer’s and other dementias were $226 billion in the US alone. No new treatment options for patients have been approv...
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ABOUT DEMENTIA - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/knowledge-center/about-dementia
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Dementia is a general term for a group of symptoms caused by disorders that impair at least two brain functions, like memory or judgement. Alzheimer’s disease is the most common type of dementia. Ability to focus and pay attention. Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). 2017 Axovant Sciences Ltd. Privacy Policy.
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Our Vision - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/about/our-vision
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Our vision at Axovant Sciences is to become the leading company focused on the treatment of dementia by comprehensively addressing the cognitive, functional, and behavioral needs of dementia patients. Our mission is to build a pipeline of late stage CNS drugs in a capital efficient manner to deliver value to patients and to shareholders. Learn More About Our Pipeline. Lorem ipsum dolor sit amet.
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Leadership Team - Axovant Sciences - A Dementia Solutions Company
http://axovant.com/about/leadership-team
Our Culture of Integrity. Resources & Compliance Personnel. REM Sleep Behavior Disorder (RBD). Axovant has assembled a team with decades of combined experience in developing, obtaining approval, and commercializing drugs for central nervous system disorders. Lawrence T. Friedhoff, MD, PhD, FACP*. Led the development of Aricept (donepezil), the top-selling drug for Alzheimer’s disease in history. Led the new drug approval team for Aciphex (rabeprazole) for the treatment of heartburn. Author of the book.
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