myclinicalpearls.blogspot.com
My Clinical Pearls
Wednesday, September 22, 2010. Well the first paper was OK. 2nd paper quite tough though. Sunday, April 25, 2010. Hematology - sickle cell anemia. 1 electrophoretic assays cannot rule out hemoglobinopathies (some variants can comigrate with HbA or HbS). 2 reticulocytes in HbS are particularly 'sticky' causing venooclusive presentations. 3 HbSC has less hemolysis but more retinopathy and aseptic bone necrosis. 5 Hydroxyurea and 5-deoxycytidine can increase HbF, thus reducing HbS load (a beta chain disease).
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