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Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

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Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

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ProfessorEBM | professorebm.blogspot.com Reviews

https://professorebm.blogspot.com

Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

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ProfessorEBM: April 2012

http://professorebm.blogspot.com/2012_04_01_archive.html

Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

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ProfessorEBM: The Demise of Protime Clinic?

http://professorebm.blogspot.com/2012/04/demise-of-protime-clinic.html

Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

3

ProfessorEBM: STAT Treatment of Status

http://professorebm.blogspot.com/2012/02/stat-treatment-of-status.html

Thursday, February 16, 2012. STAT Treatment of Status. New England Journal of Medicine. Is a randomized, double-blinded trial of IM midazolam (Versed) vs. IV lorazepam for the prehospital treatment of status epilepticus. I don't know how many paramedics read this blog, but ER docs, hospitalists and neurologists will need to be familiar with RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial), so let's review it. Orazepam has been shown to be an effective initial treatment for status. Amoxici...

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ProfessorEBM: Amoxicillin Effective for Sinusitis? It 'Snot.

http://professorebm.blogspot.com/2012/02/amoxicillin-effective-for-sinusitis-its.html

Wednesday, February 15, 2012. Amoxicillin Effective for Sinusitis? How many studies does it take to prove a lack of clinical benefit? There have been multiple randomized, controlled trials of antibiotics for acute, uncomplicated sinusitis, and meta-analyses have generally shown only a marginal benefit. That's because the majority of sinusitis cases resolve spontaneously, given enough time. So what's different about the latest RCT. Published in this issue of JAMA? Antibiotic resistance was rare.

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ProfessorEBM: March 2012

http://professorebm.blogspot.com/2012_03_01_archive.html

Thursday, March 8, 2012. Supersize Me (and My Liver). Fatty liver of a 14-year-old. What's the most common cause of newly diagnosed chronic liver disease in the U.S? It's not alcohol. It's not hepatitis C. It's nonalcoholic fatty liver disease, or NAFLD, which now accounts for 39% of new liver disease diagnoses. Nonalcoholic steatohepatitis, the more inflammatory form of NAFLD), compared to 1370 trials in hepatitis C. First, note that these were biopsy-proven. As for vitamin E, it may be tempting to thro...

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Wednesday, April 25, 2012. The Demise of Protime Clinic? The last remaining market for warfarin? The final results of the EINSTEIN-PE trial. Were published in the New England Journal of Medicine. This month. EINSTEIN-PE was a randomized, open-label trial pitting rivaroxaban, a factor Xa inhibitor, against enoxaparin overlapping with warfarin (or other vitamin K antagonist) in adults with symptomatic pulmonary embolism. The primary efficacy endpoint was recurrent venous thromboembolism. Of the 95% confide...

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