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Chronic myeloid leukemia (CML) is one of four main types of leukemia or cancer of the blood that affects about 24,800 people in the United States or about 15% of all leukemia cases in the US. (2,6)...

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Chronic myeloid leukemia (CML) is one of four main types of leukemia or cancer of the blood that affects about 24,800 people in the United States or about 15% of all leukemia cases in the US. (2,6)...
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1 gene
2 homology and alignments
3 phylogeny
4 motifs
5 ontology
6 rnai
7 chemical genetics
8 microarrays
9 protein
10 protein homology
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gene,homology and alignments,phylogeny,motifs,ontology,rnai,chemical genetics,microarrays,protein,protein homology,domains,protein interactions,future directions,at uw madison,references,sara schroeder,sschroeder3@wisc edu,powered by
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Chronic myeloid leukemia (CML) is one of four main types of leukemia or cancer of the blood that affects about 24,800 people in the United States or about 15% of all leukemia cases in the US. (2,6)...

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1

Chemical Genetics -             

http://schroedergen677s11.weebly.com/chemical-genetics.html

Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677. Chemical genetics is used to find drugs that can be used to treat diseases and help in the research of the mechanisms of diseases. Was used to determine current chemicals being used to treat CML. Each of these chemicals were analyzed used PubChem. The search resulted in 3 different chemicals. Imatinib mesylate structure (2). 1 DrugBank http:/ www.drugbank.ca/. Http:/ pubchem.ncbi.nlm.nih.gov/. 3 Fullmer, A., ...

2

Future Directions -             

http://schroedergen677s11.weebly.com/future-directions.html

Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677. There is much about CML that is not understood. Areas of research include but not limited to the mechanism of the translocation of the Philadelphia, regulation of BCR-ABL, the molecular pathway of BCR-ABL, and possible treatments using drugs to target the BCR-ABL protein and stem cells containing the Philadelphia chromosome. What is the molecular pathway of BCR-ABL and IKZF1? Phase 3 - What genes are overexpresse...

3

Motifs -             

http://schroedergen677s11.weebly.com/motifs.html

Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677. A motif is a DNA sequence or a protein sequence that is found widespread and is believed to have a biological significance. These motifs provide insight on the structure and the function of the transcribed protein in the organism. Through the use of Motif Finder, the ABL1 DNA sequence was determined to have 14 different motifs. There are as followed:. Motifs were also found using MEME. Last updated May 13, 2011.

4

RNAi -             

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Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677. RNAi is used to help determine gene function. This is performed by injecting miRNA and investigating the resulting phenotypes that vary from the wildtype. RNAi experiments have been performed on ABL1 orthologs including in the abl-1 gene in C. elegans. The phenotype was determined using Phenobank. 1 GeneCards http:/ www.genecards.org/. Wormbase http:/ www.wormbase.org/. 6 Bueno, M.J., Perez de Castro, I&#...

5

Protein -             

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Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677 at UW-Madison Spring 2010. Structure of ABL1 protein (2). Full protein name: Tyrosine-protein kinase ABL1. Amino acid length: 1130 aa. Protein accession number: P00519. Isoelectric point: 8.84. Abl1 protein sequence.rtf. The ABL1 protein is located in the cytoplasm of the cell, specifically the cytoskeleton, and the nucleus. Isoform B is also located in association with the nuclear membrane as a lipid anchor.

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Popular Press vs Primary Literature. This web page was produced as an assignment for Gen677. Chronic Myeloid Leukemia and ABL1. Normal blood sample compared to CML blood sample. Chronic myeloid leukemia (CML) is one of four main types of leukemia or cancer of the blood that affects about 24,800 people in the United States or about 15% of all leukemia cases. The severity of these symptoms determines the phase of disease. There are three phases:. 1 The chronic phase. 2 The accelerated phase. Is distinguish...

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